Resolving Inflammation using SPMs with Prof Charles Serhan

Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research.

• Prof Serhan background on moving into studying lipid mediators. (1:30)
• Aspirin triggers biosynthesis of lipid mediators. (4:57)
• Old to new: Review of inflammation and stimulating resolution processes. (6:55)
• Resolvins reduce neutrophilic infiltration and inducing “self-limitation”. (11:14)
• Plasticity of macrophage poles – key function of SPMs. (13:48)
• Healthy human breast milk contains SPMs. (19:45)
• Structures, receptors and functional location of Resolvins. (20:44)
• Downregulation of biosynthetic enzymes and using SPMs. (25:00)
• Aged mice with enhanced inflammatory response and diminished resolution response. (29:00)
• SPMs in obesity models. (31:00)
• Role of SPMs in additional chronic inflammatory conditions. (40:05)
• SPM killing and clearance of infections without immune suppression. (44:34)
• SPMs, macrophage types and tumor reduction. (46:45)
• Topical SPM application in animal models. (49:51)
• Future publication on periodontal disease. (52:53)