Episode 60

Exploring the Endocannabinoid System, PEA and OEA with Prof Daniele Piomelli


December 16th, 2020

1 hr 5 mins 24 secs

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About this Episode

Daniele Piomelli joins us from the University of California, Irvine, where he is the Louise Turner Arnold Chair in Neurosciences and Distinguished Professor of Anatomy and Neurobiology, Pharmacology and Biological Chemistry. Piomelli is the author of over 400 peer-reviewed articles in journals such as Nature, Science, Nature Medicine, PNAS and Nature Neuroscience, three books, and 34 patents. He is also the Director of the Centre for the Study of Cannabis and Editor-in-Chief of Cannabis and Cannabinoid Research, the first peer-reviewed journal entirely dedicated to the study of cannabis, its derivatives, and their endogenous counterparts in the human body. In this episode, he shares a wealth of information regarding the endocannabinoid system and the acylethanolamides, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA).


The endocannabinoid system (3:30)
The fascinating history of PEA (25:50)
The role of OEA in fat digestion (34:00)
Zoning in on PEA (42:00)
PEA dosage and time to benefit (56:00)
Synergism for pain management (59:00)

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