Episode 58

Leaky Gut - Concept or Clinical Entity? A Lesson from Dr Eamonn Quigley


November 3rd, 2020

43 mins 16 secs

Your Host

About this Episode

In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eamonn Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College.

*Highlights *

  • Debunking the gut barrier (6:00)
  • Evaluating tests to assess gut permeability (12:40)
  • Does targeting paracellular permeability improve disease? (22:00)
  • The role of the gut microbiome (29:20)
  • Maintaining the gut barrier (33:10)

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Article: Quigley EMM, 2016 – ‘Leaky gut - concept or clinical entity?’ - https://pubmed.ncbi.nlm.nih.gov/26760399/
Article: Camilleri M, 2019 – ‘Leaky gut: mechanisms, measurement and clinical implications in humans’ - https://pubmed.ncbi.nlm.nih.gov/31076401/
Article: Zuo L, Kuo WT, Turner JR - Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis - https://pubmed.ncbi.nlm.nih.gov/32304780/