Episode 41

Critically Evaluating Gene Testing in Personalised Medicine with Tommy Wood


November 21st, 2019

1 hr 1 min 42 secs

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About this Episode

Professor Tommy Wood explains the effects of specific single nucleotide polymorphisms (SNPs) on an individual’s health outcomes. From his analysis of what has been presented in the literature and widely accepted in functional medicine circles, Tommy discusses the relevance of SNP testing and highlights the difference between “relative risk” and “personal risk” whilst expanding on additional factors that should take precedence when treating a patient.

• Professor Tommy Wood discusses his journey into genetic testing and SNPs (06:00)
• Single nucleotide polymorphisms (SNPs), gene testing and phenotypes (11:21)
• Fat mass and obesity-associated SNP and obesity risk (14:15)
• FOX03 SNP and lifestyle interventions (18:44)
• SNPs associated with risk of obesity (20:00)
• Melatonin receptor 1B SNP effect on elevated fasting blood sugar (23:17)
• Pre-diabetic risk, SNPs and environmental factors (25:11)
• Catechol-O-methyltransferase SNPs, dopamine and cognitive function (32:39)
• Methylenetetrahydrofolate reductase SNPs, homocysteine and folate (38:13)
• The personalized diet and SNPs (45:27)
• The placebo/nocebo effect of genes (50:15)
• Utilising testing outside of genetic testing in clinical practice (56:58)